
Bilateral Optic Nerve Edema Leading to the Diagnosis of Ocular Syphilis
A 40-year-old Caucasian male presented with loss of vision related to bilateral optic nerve edema with serological confirmation of syphilis and…
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by Demetra Danos, OD, Mary Wittendorf, OD, FAAO, Christopher Bugajski, OD, FAAO and Robert Binkley, OD | Aug 15, 2025 | Featured Article, Neuro, Systemic Disease, Volume 3, Issue 3
A 40-year-old Caucasian male presented with loss of vision related to bilateral optic nerve edema with serological confirmation of syphilis and…
Read Moreby Sweta Das, OD, FAAO, Sherry J. Bass, OD, FAAO, Dipl ABO and Sara Weidmayer, OD, FAAO, ABCMO | May 26, 2025 | Retina, Systemic Disease, Volume 3, Issue 2
PXE is a critical multisystem disease that often presents with readily visible dermatologic manifestations and clinically typical fundus exam findings…
Read Moreby Alexia Gowing, OD and Karen Wadhams, OD, FAAO | May 20, 2025 | Sclera, Systemic Disease, Volume 3, Issue 2
This case involves a patient with Behcets’s disease and serves to demonstrate the effectiveness of oral steroid therapy as an initial therapeutic option…
Read Moreby Harriette Canellos, OD, FAAO, Dipl ABO, Daniel Kowalsky Moskaliuk, OD, Dipl. ABO and Sherry J. Bass, OD, FAAO, Dipl ABO | Feb 25, 2025 | Systemic Disease, Volume 3, Issue 1
Patients with DM1 can present with multiple complex ocular findings such as cataracts, corneal dystrophies, ptosis, and epiretinal membranes….
Read Moreby Steve Njeru, OD, MS, FAAO, Daniel Grangaard, OD, ABCMO, FAAO and William Hileman, OD, ABCMO | Feb 19, 2025 | Anterior Segment, Systemic Disease, Volume 3, Issue 1
Orbital lymphoma is the most common primary orbital tumor affecting elderly individuals with a slight predilection for females. MALT is typically a B-cell…
Read Moreby Shelly Kim, OD, FAAO | Feb 18, 2025 | Featured Article, Guess the Disease, Retina, Systemic Disease, Volume 3, Issue 1
A 49-year-old white man presented to the eye clinic due to sudden-onset scotoma in the right eye. The scotoma was inferior to fixation. He noticed it…
Read Moreby Marlin John O.D. and Caryn Herman, OD, FAAO | Nov 15, 2024 | Systemic Disease, Volume 2, Issue 4
A 48-year-old African American female presented to the clinic with a history of two episodes of transient vision loss of the left eye, occurring the night…
Read Moreby Andrew J. Crist, OD, FAAO and Ravneet K. Meeta, OD | Aug 19, 2024 | Retina, Systemic Disease, Volume 2, Issue 3
Waldenstrom macroglobulinemia (WM) is an uncommon lymphoproliferative B-cell disorder characterized by overproduction of monoclonal…
Read Moreby Emily Humphreys, OD, FAAO and Thomas Andrea OD, FAAO | Feb 24, 2024 | Retina, Systemic Disease, Volume 2, Issue 1
Severe hypertriglyceridemia can transiently cause the appearance of a salmon-colored fundus with creamy vessels which is known as lipemia retinalis
Read Moreby Shelly Kim, OD, FAAO | Feb 22, 2024 | Featured Article, Glaucoma, Neuro, Systemic Disease, Volume 2, Issue 1
Charles Bonnet Syndrome (CBS) induced by brimonidine tartrate ophthalmic solution has rarely been reported. CBS is a condition characterized by visual hallucinations in patients with vision loss and clear cognition. This condition is more prevalent in the elderly population, between the ages of 75 and 84 years old.
Read Moreby Simmy Panchal, OD, FAAO, Dipl. ABO and Kelly Singleton, OD, MS | Feb 21, 2024 | Systemic Disease, Uveitis, Volume 2, Issue 1
When a patient presents with an anterior uveitis that is suspicious for a systemic etiology, it is important to explore all areas of clinical care to determine the cause. Traditionally, the initial approach is to perform an appropriate lab work-up. Beyond this, areas of specialty that are typically considered include rheumatology, radiology, and infectious disease. However, this case report will present a patient that required intervention from dermatology to confirm the source of ocular inflammation.
Read Moreby Steve Njeru, OD, MS, FAAO, Eric Spotts, OD and Melissa Chen, OD | Nov 28, 2023 | Retina, Systemic Disease, Volume 1, Issue 3
Sickle cell disease is one of the world’s most common hemoglobinopathies, with a wide spectrum of systemic manifestations. The most common ocular…
Read Moreby Victoria Shust, OD, Rajni K. Acharya, OD, MBS, FAAO and Kristina Treml, O.D. | Nov 28, 2023 | Systemic Disease, Volume 1, Issue 3
Bilateral optic disc edema can be an ocular complication of serious conditions, emerging literature suggests a potential relationship between SLE and IIH…
Read Moreby Shannon Cummings, OD, Danielle Toms, OD and Michael W. Klein, OD, MS | Nov 27, 2023 | Anterior Segment, Neuro, Systemic Disease, Volume 1, Issue 3
Cavernous carotid aneurysms (CCAs) differ from other intracranial aneurysms in that most are asymptomatic and are generally considered benign as there is a low risk of rupture. More common than complications from rupture are complications from the mass effect of the aneurysm itself on nearby structures.1,2 This report describes a case of a giant right CCA that progressed in size despite multiple surgical repairs that resulted in near- complete ophthalmoplegia and neurotrophic keratitis which led to a perforated corneal ulcer and subsequent enucleation.
Read Moreby Grace Bissonnette, OD, FAAO, Kendra Pollard, OD, FAAO and Shikha Mehta, OD | Aug 17, 2023 | Neuro, Systemic Disease, Volume 1, Issue 2
Post-transplant lymphoproliferative disorder rarely affects the central nervous system although it can have visually significant consequences depending on the location of intracranial involvement.
Read Moreby Danielle Toms, OD and Elizabeth Phillips, OD | Aug 17, 2023 | Retina, Systemic Disease, Volume 1, Issue 2
This case demonstrates the potential difficulty in separating anterior from posterior scleritis, along with the importance of uncovering whether an episode of scleritis is infectious or non-infectious in origin.
Read Moreby Eric M. Lee, OD, FAAO, ABCMO | Aug 17, 2023 | Retina, Systemic Disease, Volume 1, Issue 2
Lab testing, when directed by the retinopathy appearance and patient demographics, can serve as an helpful method of uncovering systemic disease…
Read Moreby Jennifer T. Elder, OD, FAAO | Aug 17, 2023 | Systemic Disease, Uveitis, Volume 1, Issue 2
Uveitis can pose a clinical challenge due to the vast array of differential diagnoses. However, optometrists are well-positioned to decipher the nuances…
Read Moreby Jaclyn Lopez, OD, Kelsey Jordan, OD, MS, FAAO and Cory Siegel, MD | Aug 17, 2023 | Neuro, Systemic Disease, Volume 1, Issue 2
A 57-year-old white female presented with a complaint of intermittent binocular horizontal diplopia with dull ache behind her left eye, described as dull…
Read Moreby Janessa Visin, OD, ABCMO and Elizabeth Phillips, OD | Aug 17, 2023 | Optic Nerve, Retina, Systemic Disease, Volume 1, Issue 2
The most common systemic cause of optic neuritis continues to be multiple sclerosis.1 However, within the past decade other less common causes have been identified, such as neuromyelitis optica spectrum disorder and myelin oligodendrocyte antibody-associated disease. Previously, patients presenting with these conditions were likely grouped into having multiple sclerosis. Today, thankfully, advancements in laboratory testing and increased knowledge of the central nervous system have allowed them to be identified as distinct nosological entities. Identifying the cause of optic neuritis has many important implications, namely the ability to give an accurate prognosis, both visually and systemically.
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